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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Neurobiol Dis. 2019 Oct 17;134:104636. doi: 10.1016/j.nbd.2019.104636

Fig. 4.

Fig. 4.

AV-1980R/A induced specific B cells producing very high concentrations of antibodies.

Evaluation of humoral immune responses generated in Tg4510 transgenic mice after immunizations with AV-1980R vaccine formulated with AdvaxCpG adjuvant. (A) Detection of anti-tau antibody-secreting cells (ASC), visualized as spots, was done in splenocyte cultures obtained from experimental and control mice using ELISpot assay. (B) Concentrations of anti-tau antibodies in mouse sera were determined by ELISA. Plates were coated with Tau2–18 peptide (Genscript). Anti-tau antibody concentrations were calculated using a calibration curve generated with 1C9 anti-tau2–18 monoclonal antibody. Bars represent average ± SD (n = 11/per group).