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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Nat Metab. 2019 Dec 13;1(12):1243–1257. doi: 10.1038/s42255-019-0149-1

Extended Data Fig. 3. APP overexpression leads to adipocyte hypotrophy by impairing stimulated lipolysis (related to Figs. 4a and 4e–j).

Extended Data Fig. 3

(a) Representative images for H&E staining in sWAT sections from control mice (APP-) at different time-points of Dox 600mg/kg induction, chosen from two independent experiments, bar = 161 μm. (b) Representative H&E staining images in eWAT sections from APP transgenic mice (APP+) at different time-points of Dox 600mg/kg induction, chosen from two independent experiments, bar = 100 μm. (c-e) Lipogenesis related gene transcriptions in sWAT of APP transgenic mice at different time points of Dox 600mg/kg feeding: (c) Dgat2, (d) Fasn, (e) Scd1 and (f) Srebp1, n=3 mice per time point. Data are shown as mean ± SEM of biologically independent samples. One-way ANOVA followed by a Tukey post-test (c-f) and no statistical significance has been found.