Table 2:

Description of clusters that differed between COC groups in a whole-brain analysis

Anatomical regions in cluster	HCP_MMP1.9 area name	Volum e in mm³	X Y Z at max	COC+ M (SE)	COC− M (SE)
B. Dorsolateral prefrontal cortex	L/R_p9-46v^*, L/R_46, L/R_8Ad, L/R_s6-8, L/R_SFL, L/R_9p, L_a9-46v, L_9-46d, R_8Av, R_8C, R_8BL, R_i6-8	110,83 2	−44, 42, 16	.383 (.005)	.425 (.005)
B. Orbitofrontal cortex	L/R_OFC, L/R_13l, L/R_11l, L_a47r
B. Medial prefrontal cortex	L/R_8BM, L/R_10r, L/R_10v
B. Ventrolateral prefrontal cortex	L/R_44, L/R_p47r, L/R_IFSa, L_IFJp,
B. Frontopolar cortex	L/R_a10p, L/R_10pp
B. Motor cortices	L/R_4, L/R_6mp, L/R_6ma, L/R_SCEF, L_PEF
B. Anterior and mid cingulate cortices	L/R_s32, R_p32pr, R_24dv, R_24dd
L. Primary somatosensory cortex	L_3a
B. Cerebellum^*	n/a	21,784	−16, −94, −32	.384 (.011)	.441 (.011)
L. Ventral stream visual cortex	L_PIT
L. Early visual cortex	L_V2, L_V3, L_V4
L. Lateral occipital cortex	L_LO2
R. Posterior parietal cortex^*	R_7PC^*, R_7AL, R_PGs, R_IP1, R_LIPv	13,960	32, −52, 66	.352 (.007)	.395 (.007)
R. Somatosensory cortices	R_2
R. Posterior cingulate cortex	R_POS2, R_31pd, R_7m
L. Posterior parietal cortex^*	L_PFm^*, L_PGs, L_PGp, L_PF, L_7PC, L_IP2, L_LIPv, L_7AL	12,616	−44, −72, 46	.360 (.006)	.403 (.006)
L. Temporal parietal occipital junction	L_TPOJ3
R. Lateral temporal cortex	R_TE1p^*, R_TE2p, R_PHT	6,112	62, −64, −12	.380 (.008)	.432 (.008)
R. Cerebellum	n/a
R. Primary and early visual cortices	R_V3^*, R_V2, R_V4, R_V1	4,736	28, −86, −2	.394 (.010)	.450 (.010)
R. Lateral occipital cortex	R_LO2
L. Insula^*	L_PI^*, L_Pol1	280	−42, −2, −22	.383 (.007)	.430 (.007)
L. Auditory association cortex	L_STGa

Region at maximum value. Mean values are estimated marginal means controlling for age and other substance use.