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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Pharmacol Res. 2019 Nov 30;151:104578. doi: 10.1016/j.phrs.2019.104578

Figure 1 |. The endocannabinoid system.

Figure 1 |

The endocannabinoid system comprises of cannabinoid receptor 1 and 2 (CB1R, CB2R), their endogenous ligands 2-arachidonoylglycerol (2-AG) and anandamide (AEA) and their metabolic enzymes: diacylglycerol lipase α and β (DAGLα, DAGLβ), monoacylglycerol lipase (MGLL), α,β-hydrolase domain containing proteins 6 and 12 (ABHD6, ABHD12), N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) and fatty acid amide hydrolase (FAAH). Alternative multi-step pathways for AEA biosynthesis are not shown.