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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Pharmacol Res. 2019 Nov 30;151:104578. doi: 10.1016/j.phrs.2019.104578

Figure 5 |. Activity-based proteomics on healthy and ischemic heart tissues.

Figure 5 |

(A-C) Lysates from healthy (control) and ischemic cardiac tissues were labeled with MB108 and FP-biotin (10 μM each, 30 min, 37 °C) and analyzed by mass-spectrometry. A pre-boiled sample (10% SDS, 100 °C, 5 min) served as negative control. (A) Heatmap summary of mean abundance of hydrolases from control tissues. (B) Hydrolase activity relative to mean control. Data is expressed as mean ± SEM (n=9), t-test with Benjamini-Hochberg correction: * q < 0.05. (C) Hydrolase activity relative to mean control, ischemic samples categorized in subgroups. Data is expressed as mean ± SEM (control n=9, ischemic 1 n=5, ischemic 2 n=4), t-test with Benjamini-Hochberg correction. Control versus ischemic 1: not significant; control versus ischemic 2: # q < 0.05, ## q < 0.01.