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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Neuroimage. 2019 Dec 9;208:116450. doi: 10.1016/j.neuroimage.2019.116450

Figure 6:

Figure 6:

Comparison of hippocampus volumes before and after harmonization, correcting for age, sex, and ICV using a GAM. Studies are ordered from youngest to oldest based on median age. In the left panel, volumes were not adjusted for site. In the right panel, volumes were adjusted with ComBat-GAM, which removes location (mean) and scale (variance) differences across sites after controlling for biological covariates. Horizontal lines are plotted at constants at 0, −200, and 200 for visual aid. Comparisons for additional ROI volumes are shown in Supplementary Figure 1.