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. Author manuscript; available in PMC: 2020 Jan 24.
Published in final edited form as: Cell Rep. 2019 Dec 3;29(10):3331–3348.e7. doi: 10.1016/j.celrep.2019.10.117

Figure 3. Comprehensive Global Analysis of Differential 14-3-3 Interactors in Murine Liver.

Figure 3.

(A) Schematic of pathways contributing to potential 14-3-3 interactors within the screen.

(B) Corresponding expected patterns for contributing pathways within normalized heatmaps and hierarchical clustering analysis. 14-3-3 enrichment patterns are depicted in red, lysate analysis for expression profiles are depicted in blue. Trend bar depicts correlation between 14-3-3 enrichment and lysate patterns across conditions.

(C) Western blot analysis in biological triplicate of extracted mouse liver homogenate of activation status of additional basophilic kinases.

(D) Representative cluster of potential MK2/PKD substrates.

(E) Western blot analysis of extracted mouse liver homogenate extending MK2/PKD activation to phenformin.

(F) Representative cluster of potential AMPK substrates.

(G) Representative cluster of potential AMPKR substrates.

(H) Representative cluster of potential AKT substrates.