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. Author manuscript; available in PMC: 2020 Jul 13.
Published in final edited form as: Nat Med. 2020 Jan 13;26(1):131–142. doi: 10.1038/s41591-019-0695-9

Extended Data Fig. 9. Human AD-associated oligodendrocyte and microglia signatures identified by snRNA-seq match public datasets from aging and early onset AD populations.

Extended Data Fig. 9

Cluster markers of Micro0, Micro1, Olig0 and Oligo1 (listed in Supplementary Table 4) were used as inputs for GSEA analysis against public datasets on aging (a, GSE53890) and early onset AD patients (b, GSE39420). Genes enriched in Micro0 and Oligo0 correspond to genes previously identified as upregulated in human aging and early onset AD patients. Genes enriched in Micro1 and Oligo1 correlate with downregulation in aging and early onset AD. n=146 genes for Micro0, 178 genes for Micro1, 59 genes for Oligo0 and 233 genes for Oligo1 were used as inputs. P-value by permutation test.