Table 1.
Diagnostic Properties of Liver Enzymes in Uveal Melanoma Metastatic Disease (UM)
| ENZYME | Eskelin et al9 | |||||
|---|---|---|---|---|---|---|
| Sensitivity (%) | Specificity (%) | Likelihood Ratio (+) | ||||
| FAL | 27 | 93 | 5.0 | |||
| AST | 43 | 95 | 5.8 | |||
| ALT | 38 | 90 | 3.8 | |||
| LDH | 67 | 96 | 14.7 | |||
| COMS Report 239–90 days earlier | ||||||
| ENZYME | Sensitivity (%) | Specificity (%) | Positive predictive values (%) | |||
| Large | Medium | Large | Medium | Large | Medium | |
| FAL | 18.9 | 14.4 | 99.3 | 99.3 | 92.3 | 72.7 |
| AST | 10.0 | 7.1 | 98.9 | 99.6 | 79.2 | 66.7 |
| ALT | 12.8 | 7.3 | 98.6 | 99.4 | 80.0 | 61.5 |
| Bilirubin | 4.2 | 0 | 99.1 | 99.6 | 66.7 | 0 |
| > 1 altered (LFT) | 26.7 | 19.6 | 97.8 | 98.5 | 83.6 | 61.1 |
Note: Data from Eskelin et al.9
Abbreviations: ALT, alanine-aminotransferase; aspartate-aminotransferase (AST), FAL, alkaline phosphatase; LDH, lactic dehydrogenase; LFT, liver function tests.