Table 1.

Sequences of on-target siRNA (G0-P0), amide-modified passenger and guide strands, and non-target control siRNA (NTC) used in the RNAi experiments.

Code[a]	N[b]	RNA sequence[c]
G0-P0	0	3´-UU GUU AAG CAU CCA GUU UUA U-5´ (passenger) 5´-CAA UUC GUA GGU CAA AAU AUU-3´ (guide)
P0	0	3´-UUG UUA AGC AUC CAG UUU UAU-5´
P1	1	3´-UUG UUA AGC AUC CAG UUU UAamU-5´
P2	2	3´-UUG UUA AGC AUC CAG UUU UamAamU-5´
G0	0	5´-CAA UUC GUA GGU CAA AAU AUU-3´
G3	3	5´-pCAA UUC GUA GGU CAA AAUamAamUamU-3´
G4	4	5´-pCAA UUC GUA GGU CAA AAamUamAamUamU-3´
G5	5	5´-pCAA UUC GUA GGU CAA AamAamUamAamUamU-3´
G6	6	5´-pCAAUUCGUAGGU CAAamAamAamUamAamUamU-3´
G7	7	5´-pCAAUUCGUAGGU CAamAamAamAamUamAamUamU-3´
NTC	0	3´-UU AUC GCU GAU UUG UGU AGU U-5´ (passenger) 5´-UAG CGA CUA AAC ACA UCA A UU-3´ (guide)

^[a]P and G denote the passenger and guide strands, respectively; NTC denotes non-target control siRNA.

^[b]N is number of amide modifications.

^[c]In RNA sequences, p denotes a phosphate monoester at the 5´-end and each am denotes an internucleoside amide linkage. U or A denotes either a phosphate-to-amide (4) or amide-to-phosphate (1a or 1b) switch monomer being used during solid phase synthesis.