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Number of trials-to-mastery (top-left panel) and mean reaction time (bottom-left panel) during saline (S) and acute naltrexone tests in subjects chronically exposed to 10 mg/kg/day oxycodone (filled symbols) and in the same subjects untreated with oxycodone for 30 days (unfilled symbols). Bar graphs depict the number of subjects to exhibit withdrawal signs during the 10-min observation periods that immediately followed each acute administration of naltrexone.
