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Number of trials-to-mastery (top panel), mean reaction time (middle panel), and number of subjects to exhibit signs on withdrawal during 60-min observation periods preceding each repeated acquisition session (bottom panel) during the 10 days after oxycodone discontinuation. The gray area in the top and middle panels represent the range of trials-to-mastery and response time across subjects during the 5 sessions prior to oxycodone discontinuation.
