Figure 2. Innate immunosuppressive cytokines correlate longitudinally.

Correlation matrices of serum cytokine concentrations between time points, including A) from baseline to three months after ADT, B) from three months after ADT to time of PSA progression, and C) from baseline to time of PSA progression. Color intensity and the size of the circle are proportional to the strength of the correlation coefficient. Blue represents a positive correlation with darker colors approaching r = 1 and red represents a negative correlation with darker colors approaching r = −1. Only correlations with significance of ≤ 0.05 are shown. Empty spaces reflect correlations with p-value > 0.05. Clustering analysis was performed using H clust for 3 clusters. Pearson’s rank correlation coefficients were calculated and controlled for multiple comparisons using false discovery rates.