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. 2019 Nov 4;152(2):235–251. doi: 10.1111/jnc.14898

Figure 7.

Figure 7

Data analysis of all assay results of the caudate and putamen of the Alzheimer's disease (AD) cases chosen for β‐site APP cleaving enzyme 1 mRNA analysis (n = 10) and age‐matched controls (n = 10). (a) Oxidative damage of nucleic acid in the caudate and putamen from 10 AD cases and age‐matched controls. A p value of < 0.05 was considered significant: *indicates p < 0.05 vs. the controls. (b) Biological consequence of oxidative damage to dopamine system in the caudate and putamen from 10 AD cases and age‐matched controls. A p value of < 0.05 was considered significant,  **indicates p < 0.01 and ****indicates p < 0.0001 vs. the controls. (c) Density of vesicular monoamine transporter 2 (VMAT2) and DNA oxidative adducts levels (r s = −0.678, p = 0.015), density of VMAT2 and RNA oxidative adducts levels (r s = −0.717, p = 0.030), as well as density of dopamine D1 receptor and RNA oxidative adducts levels (r s = −0.750, p = 0.020) in the caudate from 10 AD cases. r s, the Spearman's rank correlation coefficient.