Figure 1.

Trauma survivors with adverse posttraumatic neuropsychiatric sequelae (APNS) have traditionally been evaluated in a siloed, syndrome-centered fashion (panel A), in which individual syndromes are separately diagnosed and managed. AURORA seeks to provide data to help support the ongoing transition to both a more biologically-anchored and patient-centered approach, in which discrete types of brain dysfunction (panel B) are evaluated, and the influence of the overall multidimensional context is considered in the evaluation of therapeutic targets and in understanding the response to treatments targeting specific areas of dysfunction.