Table 2.

AURORA Study assessments by domain

Assessment & Domain / Task					Timepoint
Medical Record	ED
Self-Report Questionnaire	ED	2W	8W	3M	6M	12M
Anxiety (PROMIS)	●	●	●	●	●	●
Depression (PROMIS)	●	●	●	●	●	●
PTSD (PCL-5)	●	●	●	●	●	●
Perceived Stress (PSS)	●	●	●	●	●	●
Current alcohol and tobacco use (PhenX, PROMIS)	●	●	●	●	●	●
Lifetime alcohol and tobacco use	●		●
Insomnia (ISI)	●	●	●	●	●	●
Sleep-related impairment (PROMIS)	●	●	●	●	●	●
Sleep quality (PSQI)	●	●	●	●	●	●
Nightmares (CAPS IV)	●	●	●	●	●	●
Stress-induced sleep disturbance (FIRST)	●
Panic attack during sleep		●	●	●	●	●
Chronotype (CIRENS)		●
Pain (overall, by region)	●	●	●	●	●	●
Pain interference (PROMIS)	●	●	●	●	●	●
Pain catastrophizing	●	●	●	●	●	●
Somatic Symptoms	●	●	●	●	●	●
Disability (SDS)	●	●	●	●	●	●
General mental, physical health (SF-12)	●	●	●	●	●	●
Dissociative symptoms (DES-B)	●	●	●
Rumination (RRQ)	●		●	●	●	●
Peritraumatic distress (PDI)	●
Expectations of recovery	●
Current Medications		●	●	●	●	●
Emotional support (PROMIS)		●	●	●	●	●
Social networks		●
Risk taking (RTQ)		●	●	●	●	●
Resilience (CDRS)		●	●	●	●	●
Mindfulness (FFMQ)		●	●	●	●	●
Impulsivity (SUPPS-P)		●	●	●	●	●
Distractibility (ASRS)		●	●	●	●	●
Anxiety sensitivity (ASI)		●
Personality (BFI, TIPI)		●
Childhood trauma (CTQ)		●
Lifetime trauma (LEC)			●
Emotional problem history (AAS Section D)			●
Self-efficacy (PROMIS)		●
Military service history		●
Health service utilization			●		●	●
Education (PhenX)	●
Gender (PhenX)	●
DOB	●
Sex at Birth	●
Socioeconomic status		●
Biologics	ED	1W	2W	3W	4W	6M
DNA	●		●			●
RNA	●		●			●
Plasma/EDTA	●		●			●
ACD			●			●
Saliva	●	●	●	●	●
Neurocognitive	ED	48 hour	W1–12, 3M, 6M, 9M, 12M
			Battery 1	Battery 2	Battery 3	Battery 4
Simple/Choice Reaction Time	●
TAU/NIMH Dot Probe*	●					●
Vocabulary Test		●
Gradual Onset Continuous Performance		●	●
Verbal Paired Associates Memory		●			●
Delay Discounting		●
Digit Symbol Substitution		●	●
Multiracial Emotion Identification Test		●			●
Probabilistic Reward		●
Threat/Neutral Sternberg*		●		●
Forward Digit Span		●		●
Trauma Implicit Association Test*		●				●
Cognitive Bias Test*		●		●
Belmont Emotional Sensitivity Test: Anger and Happiness*		●		●
Flash Surveys	W1	W2	W3	W4	W5	W6	W7	W8	W9	W10	W11	W12	W13-W52
Sleep	●		●	●	●		●		●		●	●	W17, Then every 7th week
Anxiety, depression, panic, hyperarousal, emotional numbing	●		●		●	●		●	●		●		W13, then every 7th week
Avoidance, re-experiencing, rumination	●		●	●		●	●		●		●	●	W18, then every 7th week
Somatic symptoms	●	●		●	●		●	●		●	●	●	W16, then every 7th week
Pain rumination	●	●	●		●		●	●		●	●		W15, then every 7th week
Self-regulation, disorganization	●					●			●				W27,52
60 second audio	●	●								●			W20,33,45,51
Smartphone-based Evaluations	W1-M12 (continuous)
Phone call log	●
Email log	●
Text log	●
Keystrokes	●
Taps and swipes	●
Location	●
Word Cloud	●
Accelerometry	●
Wearable	W1–12 (continuous)	M3–12 (variable)
Heart rate	●	●
Autonomic Nervous system	●	●
Sleep	●	●
Circadian rhythm	●	●
Activity	●	●
Temperature	●	●
Humidity	●	●
Atmospheric/air pressure	●	●
Light	●	●
In-Person Assessments	2W	6M
Startle
Dark Enhanced	●	●
Acquisition	●	●
Dot Probe	●	●
Extinction	●	●
Pain
Cold Pressor	●	●
Cuff Algometry	●	●
Temporal Summation	●	●
Pressure Pain Threshold	●	●
Conditioned Pain Modulation	●	●
fMRI
Resting state	●	●
Fearful Faces Task	●	●
Go/NoGo Task	●	●
Reward vs. Loss Task	●	●
Structural MRI
T1 Structural	●	●
DTI	●	●
Blood
DNA	●	●
RNA	●	●
Plasma	●	●
ACD	●	●
Neurocognitive Assessment
Vocabulary Test		●
Gradual Onset Continuous Performance Test		●
Verbal Paired Associates Memory Task		●
Digit Symbol Substitution Test		●
Delay Discounting Task		●
Multiracial Emotion Identification Test		●
Probabilistic Reward Task		●
Forward Digit Span		●

^*Assessments not completed by full cohort