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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Neuroimage. 2019 Oct 24;206:116307. doi: 10.1016/j.neuroimage.2019.116307

Figure 5: Plots of myelin water fraction (MWF) ROI values as a function of age (N = 125) for six of the substructures also highlighted in Fig. 4, but for which quadratic trends of MWF were significant.

Figure 5:

For each region, the coefficient of determination, R2, and the significance of the overall regression model, p, are reported. These selected regions clearly exhibited a quadratic trend of age on MWF, with significant or close to significant p values. This suggests progressive myelination continuing into middle age followed by more rapid myelin loss. We note that similar trends have recently been reported in the cerebrum (7, 21).