Radiotelemetry measurements are representative of 24 h recordings. (A) Systolic BP was higher than in age-matched NFD mice after 20 weeks on the diet (2-way ANOVA, diet effect: P<0.001). (B) Diastolic BP was higher among the groups at 20 weeks (2-way ANOVA, diet effect; P<0.04). Mean arterial pressure (MAP) was elevated at 20 and 24 weeks (2-way ANOVA, diet effect; P<0.001). (D) Heart rate did not change between experimental groups. NFD, normal fat diet (withe); HFD, high fat diet (black); Data are mean ± SEM.