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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: J Immunol. 2019 Dec 30;204(3):586–595. doi: 10.4049/jimmunol.1900677

Figure 8: CD4 T cell NGAL in kidney ischemia reperfusion injury, hypoxia –reoxygenation and T cell differentiation.

Figure 8:

NGAL expression increases in renal CD4 T cells following IR and provide functional and structural protection to kidneys. CD4 T cells that lack NGAL worsen kidney IRI due in part to increased production of pro-inflammatory IFNγ and possibly due to decreased Treg cell numbers. Furthermore, in vitro differentiation of naïve CD4 T cells leads to increased Lcn2/NGAL expression by differentiated Th1, Th2 and Th17 cells. These factors collectively lead to CD4 cell NGAL providing protection from kidney IRI.