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. Author manuscript; available in PMC: 2021 Feb 12.
Published in final edited form as: Biochem Biophys Res Commun. 2019 Nov 28;522(3):633–638. doi: 10.1016/j.bbrc.2019.11.130

Fig.1. Time-dependent inhibition of GOT1 enzyme by PF-04859989.

Fig.1

(a) Chemical structure of tested aminotransferase inhibitors that covalently bind PLP. (b) Percent inhibition of GOT1 enzymatic activity by PF-04859989, BFF-122, Vigabatrin and gabaculine. The pan-transaminase inhibitor amino-oxyacetate (AOA) was used as a positive control (c) Dose-dependency of MDH1 inhibitory activity by PF-04859989 for 24h pre-incubation time. (d) Dose-dependency of GOT1 inhibitory activity by PF-04859989 for each pre-incubation time. All data indicate mean of n=3 determinations.