Fig. 2. Repulsive steric potentials.

Schematics of the binding of a multivalent POEGMA-PDPA polymersome decorated with angiopep peptide and targeting LRP1 (A) with PMPC chains and targeting SRB1 receptors (B) and with both ligands and targeting both receptors (C). The detail of the interaction between angiopep and LRP1 (D) and PMPC and SRB1 (E) modulated by both the PEO and glycocalyx brushes. The corresponding repulsive steric potentials exerted on the LRP1 insertion in the PEO brush (F) and the polymersome inserting in the glycocalyx brush (G). These are calculated as a function of the polymersome radius, R, and insertion parameter for the PEO chains, δ_P, and for the glycocalyx HS chains, δ_G, respectively.