Table 8.
Selected GO descriptions for day 90 of gestation to birth1
| Class | GO description and ID | Size | Size in data | FDR-adj. P-value |
| Downregulated | ||||
| Biological process | Mitotic sister chromatid segregation (GO:0000070) | 90 | 86 | 0.0000 |
| Cell cycle checkpoint (GO:0000075) | 118 | 113 | 0.0000 | |
| Mitotic cytokinesis (GO:0000281) | 28 | 28 | 0.0000 | |
| Sister chromatid segregation (GO:0000819) | 110 | 104 | 0.0000 | |
| Cytokinesis (GO:0000910) | 89 | 88 | 0.0000 | |
| Cartilage condensation (GO:0001502) | 16 | 15 | 0.0000 | |
| Osteoblast differentiation (GO:0001649) | 151 | 145 | 0.0000 | |
| Ureteric bud development (GO:0001657) | 78 | 77 | 0.0000 | |
| Formation of primary germ layer (GO:0001704) | 91 | 90 | 0.0000 | |
| Endoderm formation (GO:0001706) | 42 | 41 | 0.0000 | |
| Molecular function | Motor activity (GO:0003774) | 98 | 88 | 0.0000 |
| Microtubule motor activity (GO:0003777) | 58 | 56 | 0.0000 | |
| Protein tyrosine kinase activity (GO:0004713) | 95 | 94 | 0.0000 | |
| Transmembrane receptor protein tyrosine kinase activity (GO:0004714) | 44 | 44 | 0.0000 | |
| Ephrin receptor activity (GO:0005003) | 11 | 11 | 0.0000 | |
| Extracellular matrix structural constituent (GO:0005201) | 31 | 30 | 0.0000 | |
| Voltage-gated sodium channel activity (GO:0005248) | 18 | 18 | 0.0000 | |
| Microtubule binding (GO:0008017) | 150 | 146 | 0.0000 | |
| Tubulin binding (GO:0015631) | 198 | 193 | 0.0000 | |
| Rho GTPase binding (GO:0017048) | 115 | 110 | 0.0000 | |
| Upregulated | ||||
| Biological process | Tricarboxylic acid cycle (GO:0006099) | 15 | 15 | 0.0000 |
| Citrate metabolic process (GO:0006101) | 18 | 18 | 0.0000 | |
| Tricarboxylic acid metabolic process (GO:0072350) | 22 | 22 | 0.0000 | |
| Cellular respiration (GO:0045333) | 74 | 60 | 0.0000 | |
| Aerobic respiration (GO:0009060) | 29 | 25 | 0.0000 | |
| Regulation of oxidative phosphorylation (GO:0002082) | 12 | 10 | 0.0000 | |
| Oxidative phosphorylation (GO:0006119) | 36 | 25 | 0.0000 | |
| Skeletal muscle contraction (GO:0003009) | 23 | 20 | 0.0000 | |
| Maturation of 5.8S rRNA (GO:0000460) | 10 | 10 | 0.0000 | |
| Energy coupled proton transport, down electrochemical gradient (GO:0015985) | 13 | 11 | 0.0000 | |
| Molecular function | NADH dehydrogenase (ubiquinone) activity (GO:0008137) | 18 | 11 | 0.0000 |
| NADH dehydrogenase (quinone) activity (GO:0050136) | 18 | 11 | 0.0000 | |
| NADH dehydrogenase activity (GO:0003954) | 19 | 12 | 0.0000 | |
| Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655) | 22 | 15 | 0.0000 | |
| Structural constituent of ribosome (GO:0003735) | 87 | 84 | 0.0000 | |
| Electron transfer activity (GO:0009055) | 37 | 19 | 0.0000 | |
| Triglyceride lipase activity (GO:0004806) | 12 | 11 | 0.0000 | |
| Oxidoreductase activity, acting on NAD(P)H (GO:0016651) | 50 | 41 | 0.0000 | |
| Iron-sulfur cluster binding (GO:0051536) | 32 | 31 | 0.0000 | |
| Metal cluster binding (GO:0051540) | 32 | 31 | 0.0000 |
1GO terms were identified for all genes present in the current RNA-Seq analysis data set using multivariate gene set testing, thus providing us with a robust method to identify key pathways or processes involved in myogenesis between the three time points. Size in data, number of genes from our data set present in the GO term. FDR-adj, false discovery rate adjusted P-value.