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. 2020 Jan 24;10:1130. doi: 10.1038/s41598-020-58002-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Structure of the model multi-pass membrane protein VSD4-NavAb chimera. The VSD4-NavAb chimera (PDB accession code 5EK0) is a homotetrameric protein with a central pore domain and four voltage sensing domains. Shown here is the side view of the tetramer, with one of the subunits shown in color. The sequence of the outward facing portion of the voltage sensing domain of each subunit is from VSD4 of human Nav1.7 (green) while the remainder of the sequence is that of NavAb of Arcobacter butzleri (orange).