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. 2020 Jan 24;10:1143. doi: 10.1038/s41598-020-57560-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PDD005 improves cognitive performance in aging mice. Aging WT mice were exposed by i.p. administration to PDD005 at 3 mg/kg/day or vehicle for 28 days. (A) Graph showing that PDD005 rescues cognitive deficit in aging mice 3–4 weeks after treatment. Cognitive abilities were assessed by means of the percentage of alternation in the T-maze test. One-way ANOVA with the Tukey’s multiple comparison test for post hoc analysis were performed and ***P < 0.001 indicates significant differences between PDD005 and aged vehicle group. Data expressed as means ± SEM with n = 10 mice/condition. (B,C) Plots showing the effect of PDD005 on relative mRNA expression levels of SYP (B) and PSD95 (C) in aging mice treated subchronically with PDD005. Transcriptional expression was quantified by RT-PCR and expressed as the relative expression of specific genes normalized to the housekeeping gene HPRT (2^−ΔCt). One-way ANOVA and Tukey’s multiple comparison test for post hoc analysis were performed. *P < 0.05 and **P < 0.01 indicate significant differences between PDD005 and the aged vehicle group. Data expressed as means ± SEM with n = 4–6 mice/condition.