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. 2020 Jan 24;10:1143. doi: 10.1038/s41598-020-57560-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Prohibitin 1 and 2 as targets for PDD005. MST experiments showed that PDD005 interacts with PHB1 (A) and PHB2 (C) k_D of the interaction between PDD005 and PHB1 [9.50 × 10⁻⁶ ± 4.60 M (1.05 standard error of regression; 10.76 response amplitude and 10.72 signal to noise)] and of PDD005 with PHB2 [1.29 × 10⁻⁶ ± 1.16 M (0.84 standard error of regression; 6.56 response amplitude and 8.26 signal to noise)].Control experiments of PHB1 (B) or PHB2 (D) without PDD005.