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. 2020 Jan 24;11:467. doi: 10.1038/s41467-020-14309-w

Fig. 6. LUXendin645 and LUXendin651 allow single molecule GLP1R imaging.

Fig. 6

a Representative single molecule microscopy images showing tracking of LUXendin645- and LUXendin651-labeled GLP1R at or close to the membrane (scale bar = 3 µm). b Mean square displacement (MSD) analysis showing different GLP1R diffusion modes (representative trajectories are displayed) (scale bar = 1 µm). c GLP1R molecules with diffusion coefficient D < 0.01 are classed as immobile (left), whilst those with D > 0.01 are further divided according to their anomalous diffusion exponent (α), which defines the type of motion followed (confined, normal, or directed) (right) (pooled data from n = 16 cells, 5057–8612 trajectories, six independent repeats). LUXendin645 and LUXendin651 were used at 100 pM. Source data are provided as a Source Data file.