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. 2020 Jan 24;11:498. doi: 10.1038/s41467-020-14374-1

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© The Author(s) 2020, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Representative computed tomography (CT) scans of KP mice pre- and post-treatment with vehicle (n = 8) or CB-839 (n = 10) following up to 16 days of treatment. Right control (green) and left tumour-bearing (red) limbs are highlighted. b Change in tumour size as quantified from the relative difference in size of the two limbs normalized to the control limb in KP vehicle- (n = 8) or CB-839-treated (n = 10) mice. c Change in tumour size at final CT scan following vehicle (n = 8) or CB-839 treatment (n = 10) in KP mice. Error bars are ± s.d.; *p < 0.05. d Representative CT scans of KPH2 mice pre- and post-treatment with vehicle (n = 9) or CB-839 (n = 10) following up to 21 days of treatment. Right control (green) and left tumour-bearing (red) limbs are highlighted. e Change in tumour size as quantified from the relative difference in size of the two limbs normalized to the control limb in KPH2 vehicle- (n = 9) or CB-839-treated (n = 10) mice. f Change in tumour size at final CT scan following vehicle (n = 9) or CB-839 treatment (n = 10) in KPH2 mice. Error bars are ± s.d.; *p < 0.05. g Tumour weights from vehicle- and CB-839-treated KP (vehicle n = 8; CB-839 n = 10) and KPH2 (vehicle n = 9; CB-839 n = 10) mice. Error bars are ± s.e.m.; ***p < 0.0005. h Quantification of p21⁺, phospho-histone H3⁺ (pHH3), and cleaved-caspase 3⁺ (CC3) cells per field of vision (FOV) in vehicle- and CB-839-treated animals (left to right). N = 8 with five images taken per section. Data represent mean ± s.e.m.; *p < 0.05, **p < 0.005, ***p < 0.0005. p-Values were calculated from a two-tailed Student’s t-test for c, f–h. Source data are provided as a Source Data file.