Figure 4.

Sharing of clonotypes between repertoires. (a) Venn diagram of shared clonotype frequencies between animals. (b) Shared clonotype frequencies from individual animals and total animal pool (OR Pool) with total human unique clonotype pool. (c) Distribution of CDRH3 length for unshared clonotypes from the animal pool (black) or clonotypes shared by both species pool (red). Distributions are colored as in (d). (d) Distribution of VH gene family usage for unshared clonotypes from the animal pool (black) or clonotypes shared by both species pool (red). (e,f) Sequence logos of the CDRH3s encoded by shared and unshared clonotypes of length 8 (e) or 13 (f). Head-region amino acid coloring: polar amino acids (GSTYCQN) are green; basic amino acids (KRH) are blue; acidic amino acids (DE) are red; and hydrophobic amino acids (AVLIPWFM) are black. All torso residues are gray.