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. 2020 Jan 24;11:520. doi: 10.1038/s41467-019-14196-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a (top) Side view of VRC01 bound BG505 F14 SOSIP, with the rectangle highlighting the location of interior conformational change. (bottom) Zoomed-in view showing the gp41 region around residues K567 and W571 (shown as sticks), with the cryo-EM map shown as a mesh, and the underlying fitted coordinates in cartoon representation. b (top) VRC01-bound BG505 F14 SOSIP apex-facing trimer orientation, with the rectangle highlighting the location of interior conformational change. (bottom) Zoomed-in view showing the apparent histidine triad (shown as sticks) with the cryo-EM map shown as a mesh, and the underlying fitted coordinates in cartoon representation. c Side view of histidine triad relative to gp120 and residue K567. The viewing angles in Panels b and c are identical. d Top down view of histidine triad relative to gp120. e, f Comparison between the BG505 F14/Vt8 and BG505 SOSIP layer-1/2 and gp41 HR1 conformations.