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. 2020 Jan 24;11:473. doi: 10.1038/s41467-019-14151-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Volcano plot of proteins differentially expressed by P47 and S47 MDMs. Proteins of interest most of which have eightfold or higher changes are highlighted. b Known p53 target proteins with significantly different expression in P47 and S47 MDMs. P < 0.05 (unpaired t test) and FDR <25%. c Significantly enriched functions. Bars indicate the −log₁₀(p value) with the number of proteins identified in each category next to the respective bar. The bars are color coded for their respective activation z scores. d Proteins important for macrophage innate immune response to bacterial infection are among the significantly enriched pathways in the proteomic screen P < 0.05 (unpaired t test) and FDR <25%. e Pathway analysis shows LXR/RXR activation and PPAR signaling pathways are suppressed in S47 MDMs. f Iron metabolism pathway proteins are significantly enriched in the proteomic screen P < 0.05 (unpaired t test) and FDR <25%. Source data are provided as a Source Data file.