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. 2020 Jan 24;11:481. doi: 10.1038/s41467-020-14387-w

Fig. 6. EC-specific progeroid mice are metabolically healthy at the age of 10-week old.

Fig. 6

a ITT in WT or Tie2-TRF2DN-Tg mice fed normal chow at the age of 10-week old (n = 7 biologically independent animals for WT; n = 5 biologically independent animals for Tg). b CDK inhibitor expression in stromal vascular fraction (SVF) or mature adipocytes (MA) isolated from WAT of WT or Tie2-TRF2DN-Tg mice at the age of 10-week old (n = 10 biologically independent samples each). c CDK inhibitor expression in ECs isolated from lung (n = 15 biologically independent samples for WT; n = 10 biologically independent samples for Tg), and WAT (n = 13 biologically independent samples for WT; n = 10 biologically independent samples for Tg) of WT or Tie2-TRF2DN-Tg mice at the age of 10-week old. d SA-β-Gal staining in EC and non-EC isolated from the lung of WT or Tie2-TRF2DN-Tg mice at the age of 10-week old. Bars: 100 μm. SA-β-Gal-positive cells were counted (n = 6 independent fields each). A two-tailed Student’s t test was used for difference evaluation between the two groups (b–d). Data are presented as mean ± s.e. *P < 0.05, ***P < 0.001, and ****P < 0.0001. Source data are provided as a Source Data file.