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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Biochim Biophys Acta Rev Cancer. 2019 Nov 1;1873(1):188314. doi: 10.1016/j.bbcan.2019.188314

Fig. 2. Schematic of nanoparticle therapy on HCC cells.

Fig. 2.

Top-middle, ODDCSN (organic dye-doped core-shell nanoparticle) releasing contents while bound to antibody, inducing apoptosis. Bottom-left, MTL-CEBPA binds to the CEBPA gene, increasing transcription and leading to an increase in tumor suppressor proteins causing decreased cell proliferation and metastasis. Top-right, NBTXR3 activated by SBRT, leading to intracellular release of the drug and inducing cell death. Middle-left, silica nanoparticles with a mesoporous and rattle-type (SNMRT) structures provide center of a hollow mesoporous shell to be loaded with drug and released through pores upon stimuli. Here, the silica nanoparticle is releasing chemotherapeutics inside cell to induce apoptosis.