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. Author manuscript; available in PMC: 2021 Jan 10.
Published in final edited form as: Neurosci Lett. 2019 Nov 3;715:134601. doi: 10.1016/j.neulet.2019.134601

Fig. 3.

Fig. 3.

Oligodendrocytes present antigen and activate CD8+ T cells in an EAE model and adoptive transfer of myelin-reactive T cells results in reduced numbers of oligodendrocytes, reduced remyelination and increased numbers of caspase 3/7 positive oligodendrocytes. (A) Dendritic cells, not macrophages or microglia, present myelin peptide on MHC class I and activate CD8+ T cells in an EAE model. (B) Oligodendrocytes present myelin peptide on MHC class I and activate CD8+ T cells in an EAE model. (C) Adoptive transfer of Th17 CD4+ T cells after cuprizone-mediated demyelination impairs remyelination. (D) Reduced numbers of newly born yellow fluorescent protein (YFP)-positive OPCs and mature oligodendrocytes in an adoptive transfer cuprizone model. (E) Higher percentage of caspase 3/7-positive OPCs in an adoptive transfer cuprizone model compared to cuprizone alone. (Panel A and B reprinted by permission from Springer Nature: Nature Immunology, MHC class I-restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8 T cells, Ji et al. 2013).