Table 4.

FDA Approved Liquid Biopsies

Name of Liquid Biopsy	Targets	Types of Cancer Used For	Manufacturer
CELLSEARCH® Circulating Tumor Cell Assay	Detects circulating tumor cells (CTC) of epithelial origin (CD45−, EpCAM+, and cytokeratins 8, 18+, and/or 19+)	Metastatic breast, prostate, and colorectal cancer	Menarini Silicon Biosystems
cobas® EGFR Mutation Test v2	Detects 42 mutations in exons 18, 19, 20 and 21 of the epidermal growth factor receptor (EGFR) gene, including the T790M resistant mutation	Non-small cell lung cancer (NSCLC)	Roche Molecular Systems
therascreen® PIK3CA RGQ PCR kit.	Detects 11 mutations in exons 7, 9, and 20 of the PIK3CA gene	PIK3CA mutated HR+/HER2− advanced breast cancer	QIAGEN