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. 2019 Oct 17;13(1):45–60. doi: 10.1007/s12195-019-00602-2

Figure 8.

Figure 8

CCN4 is associated with reduced expression of DNA replication and cell cycle genes and increased expression of PI3K-Akt signaling and extracellular matrix genes in human melanoma cell lines. The expression of a subset of genes associated with DNA replication (a), cell cycle (b), PI3K-Akt signaling (c), transcription factors (d), and extracellular matrix (e) are plotted against CCN4 expression assayed by RNA-seq within 56 melanoma cell lines, as reported by the CCLE. Filled circles highlight the values for RPMI-7951 (red), SK-MEL-24 (blue), SK-MEL-3 (black), and SH-4 (yellow) cell lines. Dotted lines indicate the expression threshold used for determining whether the expression of a particular gene is high or low for the Fisher’s exact test. N.D. indicates that CCN4 was not detected.