Table 8.

The list of most dysregulated miRNAs with their targets involved in neuron death, in bortezomib-treated SH-SY5Y cells compared to controls. Presented miRNAs downregulate expression of their target genes, hence the direction of target genes regulation is marked as “↓”. Since all miRNAs have decreased expression (negative fold change), the downregulation of their targets is not prominent and therefore they present with positive fold change, which indicates increased expression of genes related to neuron death.

miRNA	Fold Change miRNA	Direction of Target Gene Regulation	Target Genes	Fold Change Target Gene mRNA
hsa-miR-6880-5p	−2.46	↓	C12orf5 (chromosome 12 open reading frame 5)	2.07
hsa-miR-26b-5p	−2.22	↓	DDIT4 (DNA-damage-inducible transcript 4)	2.76
			HSPD1 (heat shock 60kDa protein 1 (chaperonin))	2.09