OI 10.41	Patient age: affects ultimate tensile strength, elastic modulus, maximum deformation, and Brinell hardness [190] and the bone structure in such a way that increases its fracture risk [191].
OI 10.42	Diseases: affect the rate of bone remodelling, see Remark 19, and consequently the percentage of bone mineral content (OI 10.23) and BMD distribution, i.e., the mechanical properties of bone [192,193,194]. Fracture risk analysis in unhealthy, e.g., metastatic, bones is currently even less accurate than fracture risk analysis in healthy bones [195].
OI 10.43	Nutrition: a well-balanced diet (including plant-based diets [196,197,198,199,200]) alongside an adequate intake of Calcium and Vitamin D (sunlight exposure time) may reduce osteoporosis-induced fracture risk and hospital costs [196,201].
OI 10.44	Physical activity: increases not only quality of life [202,203], but also BMD and bone mechanical properties values [204]. Furthermore, regular exercise enhances bone mass and strength, and reduces bone fracture risk [205].