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. 2019 Dec 18;21(1):8. doi: 10.3390/ijms21010008

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Nepn null mice have normal glucose regulatory function and body weight. (a) Intraperitoneal Glucose Tolerance Test (IPGTT). Evaluation of blood glucose of Nepn^−/− mice compared to Nepn^+/+ in a group of 4–6 months old mice. Blood glucose was measured at the indicated time points after intraperitoneal glucose injections (Nepn^+/+: seven mice; Nepn^−/−: seven mice). The plasma glucose concentration peaked at 15 min after the glucose challenge and then gradually returned to normal level throughout the experiment—no significant differences between wild-type and Nepn null mice can be observed (p = 0.9, n = 7 for each group). Data are expressed as the mean ± SD. (b) The bodyweight of 4 and 6 months old mice were from wild-type and Nepn null groups. Results are means ± SD. T-test revealed no discernible differences between the genotypes (p = 0.26, n = 6 for each group).