Table 2.
The epigenetic changes found in patients with T1DM: Histone modification.
| Publication | Specific Target | Type of Cells | Results |
|---|---|---|---|
| (1st Author + Year) | |||
| Miao, 2008 [46] | genome-wide + H3K9me2 | monocytes | no differences |
| lymphocytes | ↑ H3K9me2 | ||
| Miao, 2012 [47] | T1DM susceptible loci | monocytes | differences in H3K9Ac: |
| + H3K9Ac, H4K16Ac, | ↑ HLA-DQB1, ↓ HLA-DRB1 | ||
| H3K4, H3K9, H3K27 me3 | lymphocytes | no differences | |
| Chen, 2009 [50] | genome-wide H4 acetylation | monocytes | ↑ H4 acetylation |
| Liu, 2015 [51] | genome-wide H3 acetylation | CD4+ T cells | ↓ H3 acetylation |
H3K9me2—dimethylation of lysine 9 of histone 3. H3K9Ac, H4K16Ac—acetylation of lysine 9 of histone 3, and of lysine 16 of histone 4. H3K4, H3K9, H3K27 me3—trimethylation of lysine 4, 9, and 27 of histone 3. ↓ Decrease of histone modification. ↑ Increase of histone modification.