Table 1.
Disease | miRNA | Expression | Target | References |
---|---|---|---|---|
Cardiac hypertrophy | miRNA-1 | Downregulated | Mef2a; Gata4 | [93,94,95] |
miRNA-133 | Downregulated | GDP–GTP exchange protein; Cdc42 | [93,96,97] | |
miRNA-208a | Downregulated | Myh7 | [18,98,99] | |
Ischemia/reperfusion injury | miRNA-24-3p | Downregulated | Keap1/Nrf2 | [109] |
miRNA-144 | Downregulated | FoxO1 | [110,111] | |
miRNA-302 | Upregulated | Mcl-1 | [113] | |
miRNA-23a | Upregulated | MnSOD | [117] | |
Heart transplantation | miRNA-10a | Downregulated | NF-κB | [126] |
miRNA-31 | Upregulated | TNF-α | [127] | |
miRNA-92a | Upregulated | Integrin a5, S1P1, MKK4, eNOS | [128] | |
miRNA-155 | Upregulated | T-cell receptor, IFN receptor | [164] | |
Coronary artery diseases | miRNA-24 | Downregulated | Ogt, Keap1/Nrf2 | [132,134,135,136,137] |
miRNA-92a | Upregulated | HO-1 | [138] | |
miRNA-199a | Downregulated | SIRT1 | [139] | |
Heart failure | miRNA-199b | Upregulated | calcineurin/NFAT | [101,157,158,159] |
miRNA-21 | Upregulated | natriuretic peptide B | [156,163] |
Mef2a—Myocyte-specific enhancer factor 2A, Gata4—Transcription factor GATA-4, GDP–GTP exchange protein–guanosine diphosphate–guanosine triphosphate exchange protein, Cdc42—Cell division control protein 42, Myh7—beta myosin heavy chain, Keap1/Nrf2—Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2-related factor 2, FoxO1–Forkhead box protein O1, Mcl-1—Myeloid cell leukemia 1, MnSOD—manganese-dependent superoxide dismutase, NF-κB–nuclear factor kappa B, TNF-α–tumor necrosis factor alpha, S1P1–Sphingosine-1-phosphate receptor 1, MKK4—Mitogen-activated protein kinase kinase 4, eNOS—Endothelial nitric oxide synthase, INF receptor–interferon receptor, Ogt—O-linked β-N-acetylglucosamine transferase, HO-1—Heme oxygenase 1, SIRT1—sirtuin 1, NFAT—Nuclear factor of activated T cells.