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. 2020 Jan 5;21(1):358. doi: 10.3390/ijms21010358

Table 1.

List of selected miRNAs with function in oxidative-stress-induced cardiovascular diseases.

Disease miRNA Expression Target References
Cardiac hypertrophy miRNA-1 Downregulated Mef2a; Gata4 [93,94,95]
miRNA-133 Downregulated GDP–GTP exchange protein; Cdc42 [93,96,97]
miRNA-208a Downregulated Myh7 [18,98,99]
Ischemia/reperfusion injury miRNA-24-3p Downregulated Keap1/Nrf2 [109]
miRNA-144 Downregulated FoxO1 [110,111]
miRNA-302 Upregulated Mcl-1 [113]
miRNA-23a Upregulated MnSOD [117]
Heart transplantation miRNA-10a Downregulated NF-κB [126]
miRNA-31 Upregulated TNF-α [127]
miRNA-92a Upregulated Integrin a5, S1P1, MKK4, eNOS [128]
miRNA-155 Upregulated T-cell receptor, IFN receptor [164]
Coronary artery diseases miRNA-24 Downregulated Ogt, Keap1/Nrf2 [132,134,135,136,137]
miRNA-92a Upregulated HO-1 [138]
miRNA-199a Downregulated SIRT1 [139]
Heart failure miRNA-199b Upregulated calcineurin/NFAT [101,157,158,159]
miRNA-21 Upregulated natriuretic peptide B [156,163]

Mef2a—Myocyte-specific enhancer factor 2A, Gata4—Transcription factor GATA-4, GDP–GTP exchange protein–guanosine diphosphate–guanosine triphosphate exchange protein, Cdc42—Cell division control protein 42, Myh7—beta myosin heavy chain, Keap1/Nrf2—Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2-related factor 2, FoxO1–Forkhead box protein O1, Mcl-1—Myeloid cell leukemia 1, MnSOD—manganese-dependent superoxide dismutase, NF-κB–nuclear factor kappa B, TNF-α–tumor necrosis factor alpha, S1P1–Sphingosine-1-phosphate receptor 1, MKK4—Mitogen-activated protein kinase kinase 4, eNOS—Endothelial nitric oxide synthase, INF receptor–interferon receptor, Ogt—O-linked β-N-acetylglucosamine transferase, HO-1—Heme oxygenase 1, SIRT1—sirtuin 1, NFAT—Nuclear factor of activated T cells.