Table 2.
Genotype frequencies of complement factor D (CFD) and complement factor H (CFH) between patients with RPL and controls.
| Genotypes | Controls (n = 384) |
RPL Patients (n = 412) |
AOR (95% CI) * | p | FDR-p |
|---|---|---|---|---|---|
| CFD rs2230216 C>G | |||||
| CC | 306 (79.7) | 317 (76.9) | 1.000 (reference) | ||
| CG | 72 (18.8) | 93 (22.6) | 1.225 (0.866–1.732) | 0.252 | 0.397 |
| GG | 6 (1.6) | 2 (0.5) | 0.302 (0.060–1.513) | 0.145 | 0.305 |
| Dominant (CC vs. CG+GG) | 1.154 (0.822–1.621) | 0.408 | 0.643 | ||
| Recessive (CC+CG vs. GG) | 0.296 (0.059–1.481) | 0.138 | 0.290 | ||
| HWE-p | 0.461 | 0.078 | |||
| CFH rs1065489 G>T | |||||
| GG | 109 (28.4) | 123 (29.9) | 1.000 (reference) | ||
| GT | 199 (51.8) | 208 (50.5) | 0.921 (0.666–1.272) | 0.617 | 0.648 |
| TT | 76 (19.8) | 81 (19.7) | 0.931 (0.620–1.398) | 0.731 | 0.768 |
| Dominant (GG vs. GT+TT) | 0.926 (0.682–1.258) | 0.624 | 0.655 | ||
| Recessive (GG+GT vs. TT) | 0.983 (0.693–1.396) | 0.925 | 0.971 | ||
| HWE-p | 0.387 | 0.680 | |||
| CFH rs1061170 T>C | |||||
| TT | 325 (84.6) | 370 (89.8) | 1.000 (reference) | ||
| TC | 59 (15.4) | 42 (10.2) | 0.625 (0.409–0.954) | 0.029 | 0.091 |
| CC | 0 (0.0) | 0 (0.0) | N/A | N/A | N/A |
| Dominant (TT vs. TC+CC) | 0.625 (0.409–0.954) | 0.029 | 0.091 | ||
| Recessive (TT+TC vs. CC) | N/A | N/A | N/A | ||
| HWE-p | 0.103 | 0.276 |
* The odds ratio was adjusted by age. CFD, complement factor D; CFH, complement factor H; RPL, recurrent pregnancy loss; AOR, adjusted odds ratio; 95% CI, 95% confidence interval; HWE, Hardy–Weinberg equilibrium; FDR, false-positive discovery rate.