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. 2019 Dec 27;21(1):203. doi: 10.3390/ijms21010203

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Comparison of corin-Tg(i) and wild-type (WT) control mice. (a) Schematic presentation of corin structure with individual domains: cytoplasmic domain (CD), transmembrane domain (TM), frizzled domain1 (Fz1), low-density lipoprotein receptor (LDLR) repeats, frizzled domain2 (Fz2), macrophage scavenger receptor (SR)-like domain, and catalytically inactive protease domain with catalytic triad containing histidine (H₉₁₀), aspartate (D₉₅₉), and serine (S) to alanine (A) mutation at positions 1052 (S/A₁₀₅₂) [25,31,32]. (b) Representative image of corin-Tg(i) and WT littermate female mice at 90 days (upper panel), and corresponding hearts (lower panel). (c) Kaplan–Meier survival curves of female and male corin-Tg(i) vs. sex-matched WT mice (n = 125–181 per group). (d) Comparison of heart weight (HW), body weight (BW), (left Y-axis), and heart weight to body weight ratio (HW/BW) (right y-axis) of corin-Tg(i) vs. WT female control mice. Data are represented as mean ± SE.