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. 2019 Dec 27;21(1):203. doi: 10.3390/ijms21010203

Figure 3.

Figure 3

Cardiac corin-Tg(i) overexpression reduces pleural effusion, edema, and systemic water retention in female mice with DCM. (a) Pleural effusions (PE) prevalence; bars represent percent affected mice analyzed by Fishers exact test and (b) lung weight-to-body weight ratio (LW/BW) at 90 days of age, analyzed by one-way ANOVA with Newman–Keuls multiple comparison test. The number of mice per group is shown and the values for control mice without DCM (corin-WT/WT, wt,wt) are indicated by dotted lines (n = 8). (c) Age-related changes in extracellular water (ECW). Experimental groups were: Corin-Tg(i)/DCM (●, tg,tg, n = 6–11), corin-WT/DCM (●, wt,tg, n = 20–25), and WT (dotted lines, n = 15–18) mice. Data are represented as mean ± SE; **** p < 0.0001, ** p < 0.01 (tg,tg or wt,tg vs. wt,wt); ++++ p < 0.0001, ++ p < 0.01 (tg,tg vs. wt,tg).