Table 7.
Examples of patents of dendrimers as drug-delivery systems.
| Pharmaceutical Application | Dendrimer | Drug loaded | Summary | Publication Date | Patent | Reference |
|---|---|---|---|---|---|---|
| Gene delivery | PAMAM | MicroRNA-150 (miR-150) | A PAMAM dendrimer was designed for sustained delivery of miR-150 to FLT3-overexpressing acute myeloid leukemia cells. Preclinical animal model studies have demonstrated good therapeutic efficacy. | 2019 | US20190175754 | [130] |
| CNS drug delivery | PAMAM | Prion protein (PrP) | PrP was conjugated to PAMAM dendrimers for Alzheimer’s therapy. This complex will inhibit β-amyloid plaque formation (they act as potent neurotoxins in vitro and in vivo in Alzheimer’s disease). | 2019 | US20190092837 | [131] |
| Tumor drug delivery | PAMAM | Disulfiram | Disulfiram and photosensitizer indocyanine green were entrapped into PAMAM-G0 dendrimer for anti-tumor therapy. This prepared a nanodrug-delivery system that can simultaneously play roles of chemotherapy and photodynamic therapy. | 2018 | CN108888764 | [132] |
| Tumor targeting and controlled drug release | PAMAM | Doxorubicin(DOX) | Tumor targeting and controlled drug release of the DOX-PEG-PAMAM dendritic complex is controlled by the pH. | 2017 | CN107596385 | [133] |
| Tumor targeting | PAMAM | Erlotinib | The Erlotinib–PAMAM dendrimer will target tumor cells with a high expression of CD44 and can specifically deliver more drugs to the tumor site. | 2017 | CN107281164 | [134] |
| Targeted drug delivery | PLL | Polynucleotides | The rabies virus glycoprotein (RVG) was conjugated to the PLL dendrimer to provide effective and safe delivery of polynucleotides to target cells. | 2012 | KR1020120067168 | [135] |
| Gene delivery | PLL | Plasmid DNA | A PLL system containing a vector with intracellular nuclear protein binding and reducible polymers is provided to stabilize plasmid DNA in an extracellular region, and to promote its absorption to the target cell. | 2012 | KR1020120007208 | [136] |
| Cancer targeting | Peptide-dendrimer | Docetaxel | The peptide was conjugated with the dendrimer for targeting, imaging, and treatment of prostate cancer. | 2018 | EP3402484 | [137] |
| Vaccine | Positively charged dendrimer | Antigen | Branched polymeric dendrimers (e.g., PAMAM and other dendrimers) were used as vehicles for the targeted delivery of antigen to specific cells, giving rise to a new nanoparticle-based method for genetic or protein vaccination. | 2018 | US20180099032 | [138] |
| Drug-delivery system | Asymmetric dendrimer | Paclitaxel | Paclitaxel-loading asymmetric dendrimer nanometer drug carrier system has the anti-tumor treatment index and biosecurity enhanced compared with those of free Paclitaxel during the in vivo treatment. | 2017 | CN106512021 | [139] |
| Transdermal drug delivery and permeation enhancer | Second-generation oleodendrons | Diclofenac | Oleic acid-based dendron is used as a potential chemical penetration enhancer in transdermal drugs. | 2013 | IN1749/MUM/2010 | [140] |