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Stimulation of collagen expression in cultured dermal fibroblasts and ex vivo skin tissue. Increased expression of collagen I by tested peptides was observed in cultured human dermal fibroblasts by enzyme-linked immunosorbent assay (ELISA) (a). Ex vivo skin tissue treated with tested peptides were stained by Masson’s Trichrome staining (b), showing significantly increased intensity in peptides complex treated tissue (c). (bar = 100 mm). (*: p < 0.05; **: p < 0.01; ***: p < 0.001).
