Table 1.

Docking scores of original cyclopropane derivatives in histone deacetylase 4 (HDAC4) and histone deacetylase 5 (HDAC5) receptors.

Compound	Inhibitor Strength	HDAC4 IC50 (µM)	HDAC4 Docking Score −log10 (Kd)
40	Strong	0.02	8.82
49	Strong	0.02	8.45
31	Strong	0.02	8.22
19	Moderate	0.33	8.17
25	Strong	0.05	8.00
30	Strong	0.05	7.98
22	Strong	0.08	7.73
15	Moderate	0.34	7.43
35	Moderate	0.10	7.17
33	Moderate	0.54	6.61
Average			7.86