Anti-obesity mechanisms of action described in in vivo studies. pACC: phosphorylated acetyl-CoA carboxylase, AdipoR1: adiponectin receptor 1, pAMPK: phosphorylated AMP-activated protein kinase, AP2: fatty acid binding protein, BAT: brown adipose tissue, C/EBPα: CCAAT-enhancer-binding protein α, CPT: carnitine palmitoyltransferase, FABP: fatty acid binding protein, FAS: fatty acid synthase, LIPE: hormone sensitive lipase, LPL: lipoprotein lipase, PGC-1α: peroxisome proliferator-activated receptor gamma co-activator 1α, PPARγ: peroxisome proliferator activated receptor γ, PGC1α: PPARG coactivator 1 alpha, PRDM16: PR domain-containing 16, SIRT1: sirtuin 1, SREBP1c: sterol regulatory element-binding protein 1c, UCP1: uncoupling protein 1, WAT: white adipose tissue. ↑ significant increase, ↓: significant decrease.