Table 2.
Summary of anti-inflammatory and antioxidant activities of balsacones.
| Molecule | NO Inhibition IC50 (μM) 1 | Antioxidant IC50 (μM) 2 |
|---|---|---|
| Balsacone A | 17 ± 1 µM | 3.1 ± 0.5 µM |
| Balsacone B | 13.3 ± 0.8 µM | 1.05 ± 0.09 µM |
| Balsacone C | 29 ± 1 µM | 1.10 ± 0.08 µM |
| (±)-Balsacone K | 10.49 ± 0.07 µM | 1.8 ± 0.3 µM |
| (±)-Iryantherin-D | 26.9 ± 0.5 µM | 5.1 ± 0.8 µM |
1 L-NAME (1 mM), used as an anti-inflammatory positive control, produced an inhibition of NO production of 68%; 2 Quercetin, used as an antioxidant positive control, had an IC50 of 0.082 ± 0.008 µg/mL. All the experiments were carried out in triplicate and presented results are representative of at least two different experiments.