Figure 5.

The effects of ADSC-CM on UVB-induced activation of MAPK/AP-1 signaling. HaCaTs (a) and NHDFs (b) were irradiated with UVB, followed by treatment with 50% or 100% ADSC-CM for 1 h and 4 h, respectively. The phosphorylation levels of ERK, JNK, p38, c-Jun, and c-Fos were measured by western blotting. The results are shown as the mean ± SD of at least three independent experiments. ^# p < 0.05, ^## p < 0.01, and ^### p < 0.001, compared with the non-irradiated control. * p < 0.05, ** p < 0.01, and *** p < 0.001, compared with the irradiated, ADSC-CM free control.