Table 2.
Expression levels of sirtuin-1–7 genes by diagnostic group.
| Study 1 | Study 2 | ||||||
|---|---|---|---|---|---|---|---|
| Gene | OD | NOF | ≥40 | NOF | EM | PR | PCOS |
| SIRT1 | 225.2 ± 46.0 a | 169.1 ± 11.7 a | 478.3 ± 111.1 b | 169.1 ± 11.7 a | 139.3 ± 16.2 a | 166.4 ± 30.2 a | 138.5 ± 36.4 a |
| SIRT2 | 271.4 ± 36.6 a | 161 ± 16.1 a | 600.1 ± 97.0 b | 161 ± 16.1 a | 637.5 ± 57.1 b/c | 793.0 ± 97.7 b | 460.4 ± 68.5 c |
| SIRT3 | 70.8 ± 8.9 a | 72.1 ± 3.1 a | 115.3 ± 27.6 a | 72.1 ± 3.1 a | 117.7 ± 14.7 a/b | 150.9 ± 34.3 b | 84.3 ± 14.3 a/b |
| SIRT4 | 2.5 ± 0.6 a | 4.3 ± 0.3 a | 2.7 ± 0.9 a | 4.3 ± 0.3 a | 1.9 ± 0.2 a | 3.6 ± 0.9 a | 2.01 ± 0.6 a |
| SIRT5 | 83.2 ±10.5 a | 79.2 ± 4.9 a | 171.6 ± 37.2 b | 79.2 ± 4.9 a | 143.8 ± 18.1 a/b | 169.7 ± 22.2 b | 146.8 ± 20.3 a/b |
| SIRT6 | 3.2 ± 0.7 a | 4.4 ± 0.5 a | 2.5 ± 0.5 a | 4.4 ± 0.5 a | 6.3 ± 1.3 a | 13.8 ± 3.8 b | 4.7 ± 1.6 a |
| SIRT7 | 32.7 ± 7.3 a | 68.6 ± 8.8 a | 66.5 ± 14.5 a | 68.6 ± 8.8 a | 104.9 ± 11.3 a | 151.2 ± 30.8 b | 91.4 ± 17.2 a/b |
Results were determined by qRT-PCR and are expressed as mean ± standard error. Different lowercase letters (a, b and c) represent statistically significant differences of the means in each study. Gene expression values are ×105 relative to β-actin expression.